The Fischer projection formula of the aldotetrose represented by the model is to be drawn and the configuration as R or S is to be assigned to each chirality center. Concept introduction: In Fischer projection formula, a tetrahedral carbon is represented by two crossed lines. The horizontal line represents bonds coming out of the page and vertical lines represent bonds moving in to the page. For assigning R or S configuration, the four groups attached to the chiral center are arranged in the order of priority by applying sequence rules. The molecule is then oriented in such a way that the group of lowest priority points away from the viewer. If the arrangement of highest priority to second highest priority to third highest priority is clockwise then R configuration is assigned. If the arrangement of highest priority to second highest priority to third highest priority is counterclockwise then S configuration is assigned. To draw: The Fischer projection formula of the aldotetrose represented by the model and to assign the configuration as R or S to each chirality center.

Question

Diltiazem is prescribed to treat hypertension, and simvastatin is a cholesterol-lowering drug. Locate the chirality centers in each.

Answer 1

Question

Chapter 25.2, Problem 5P

Interpretation Introduction

Interpretation:

The Fischer projection formula of the aldotetrose represented by the model is to be drawn and the configuration as R or S is to be assigned to each chirality center.

Concept introduction:

In Fischer projection formula, a tetrahedral carbon is represented by two crossed lines. The horizontal line represents bonds coming out of the page and vertical lines represent bonds moving in to the page.

For assigning R or S configuration, the four groups attached to the chiral center are arranged in the order of priority by applying sequence rules. The molecule is then oriented in such a way that the group of lowest priority points away from the viewer. If the arrangement of highest priority to second highest priority to third highest priority is clockwise then R configuration is assigned. If the arrangement of highest priority to second highest priority to third highest priority is counterclockwise then S configuration is assigned.

To draw:

The Fischer projection formula of the aldotetrose represented by the model and to assign the configuration as R or S to each chirality center.

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Diltiazem is prescribed to treat hypertension, and simvastatin is a cholesterol-lowering drug. Locate the chirality centers in each.

Consider the following compounds: CO,H СНО ОНС. ОНС CO,H H3C H. H H3C ОН ČO,H H. CH3 HỌ A B (a) Label the asymmetric carbons as R or S on each compound (A - C). (b) Which compounds, if any, are enantiomers? diastereomers? identical?

Convert each compound to a Fischer projection, and label eachstereogenic center as R or S.

Answer 2

Question

Chapter 25.2, Problem 5P

Interpretation Introduction

Interpretation:

The Fischer projection formula of the aldotetrose represented by the model is to be drawn and the configuration as R or S is to be assigned to each chirality center.

Concept introduction:

In Fischer projection formula, a tetrahedral carbon is represented by two crossed lines. The horizontal line represents bonds coming out of the page and vertical lines represent bonds moving in to the page.

For assigning R or S configuration, the four groups attached to the chiral center are arranged in the order of priority by applying sequence rules. The molecule is then oriented in such a way that the group of lowest priority points away from the viewer. If the arrangement of highest priority to second highest priority to third highest priority is clockwise then R configuration is assigned. If the arrangement of highest priority to second highest priority to third highest priority is counterclockwise then S configuration is assigned.

To draw:

The Fischer projection formula of the aldotetrose represented by the model and to assign the configuration as R or S to each chirality center.

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Answer 3

Question

Chapter 25.2, Problem 5P

Interpretation Introduction

Interpretation:

The Fischer projection formula of the aldotetrose represented by the model is to be drawn and the configuration as R or S is to be assigned to each chirality center.

Concept introduction:

In Fischer projection formula, a tetrahedral carbon is represented by two crossed lines. The horizontal line represents bonds coming out of the page and vertical lines represent bonds moving in to the page.

For assigning R or S configuration, the four groups attached to the chiral center are arranged in the order of priority by applying sequence rules. The molecule is then oriented in such a way that the group of lowest priority points away from the viewer. If the arrangement of highest priority to second highest priority to third highest priority is clockwise then R configuration is assigned. If the arrangement of highest priority to second highest priority to third highest priority is counterclockwise then S configuration is assigned.

To draw:

The Fischer projection formula of the aldotetrose represented by the model and to assign the configuration as R or S to each chirality center.

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Answer 4

Question

Chapter 25.2, Problem 5P

Interpretation Introduction

Interpretation:

The Fischer projection formula of the aldotetrose represented by the model is to be drawn and the configuration as R or S is to be assigned to each chirality center.

Concept introduction:

In Fischer projection formula, a tetrahedral carbon is represented by two crossed lines. The horizontal line represents bonds coming out of the page and vertical lines represent bonds moving in to the page.

For assigning R or S configuration, the four groups attached to the chiral center are arranged in the order of priority by applying sequence rules. The molecule is then oriented in such a way that the group of lowest priority points away from the viewer. If the arrangement of highest priority to second highest priority to third highest priority is clockwise then R configuration is assigned. If the arrangement of highest priority to second highest priority to third highest priority is counterclockwise then S configuration is assigned.

To draw:

The Fischer projection formula of the aldotetrose represented by the model and to assign the configuration as R or S to each chirality center.

Expert Solution & Answer

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Answer 5

Chapter 25.2, Problem 5P

Interpretation Introduction

Interpretation:

The Fischer projection formula of the aldotetrose represented by the model is to be drawn and the configuration as R or S is to be assigned to each chirality center.

Concept introduction:

In Fischer projection formula, a tetrahedral carbon is represented by two crossed lines. The horizontal line represents bonds coming out of the page and vertical lines represent bonds moving in to the page.

For assigning R or S configuration, the four groups attached to the chiral center are arranged in the order of priority by applying sequence rules. The molecule is then oriented in such a way that the group of lowest priority points away from the viewer. If the arrangement of highest priority to second highest priority to third highest priority is clockwise then R configuration is assigned. If the arrangement of highest priority to second highest priority to third highest priority is counterclockwise then S configuration is assigned.

To draw:

The Fischer projection formula of the aldotetrose represented by the model and to assign the configuration as R or S to each chirality center.

Answer 6

Chapter 25.2, Problem 5P

Interpretation Introduction

Interpretation:

The Fischer projection formula of the aldotetrose represented by the model is to be drawn and the configuration as R or S is to be assigned to each chirality center.

Concept introduction:

In Fischer projection formula, a tetrahedral carbon is represented by two crossed lines. The horizontal line represents bonds coming out of the page and vertical lines represent bonds moving in to the page.

For assigning R or S configuration, the four groups attached to the chiral center are arranged in the order of priority by applying sequence rules. The molecule is then oriented in such a way that the group of lowest priority points away from the viewer. If the arrangement of highest priority to second highest priority to third highest priority is clockwise then R configuration is assigned. If the arrangement of highest priority to second highest priority to third highest priority is counterclockwise then S configuration is assigned.

To draw:

The Fischer projection formula of the aldotetrose represented by the model and to assign the configuration as R or S to each chirality center.

Answer 7

Chapter 25.2, Problem 5P

Interpretation Introduction

Interpretation:

The Fischer projection formula of the aldotetrose represented by the model is to be drawn and the configuration as R or S is to be assigned to each chirality center.

Concept introduction:

In Fischer projection formula, a tetrahedral carbon is represented by two crossed lines. The horizontal line represents bonds coming out of the page and vertical lines represent bonds moving in to the page.

For assigning R or S configuration, the four groups attached to the chiral center are arranged in the order of priority by applying sequence rules. The molecule is then oriented in such a way that the group of lowest priority points away from the viewer. If the arrangement of highest priority to second highest priority to third highest priority is clockwise then R configuration is assigned. If the arrangement of highest priority to second highest priority to third highest priority is counterclockwise then S configuration is assigned.

To draw:

The Fischer projection formula of the aldotetrose represented by the model and to assign the configuration as R or S to each chirality center.

Answer 8

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Answer 19

Ch. 25.1 - Prob. 1P Ch. 25.2 - Prob. 2P Ch. 25.2 - Prob. 3P Ch. 25.2 - Prob. 4P Ch. 25.2 - Prob. 5P Ch. 25.3 - Prob. 6P Ch. 25.3 - Prob. 7P Ch. 25.4 - Prob. 8P Ch. 25.4 - Prob. 9P Ch. 25.4 - Prob. 10P

Solution Summary: The author explains the Fischer projection formula of the aldotetrose represented by the model and assigns the configuration as R or S to each chirality center.

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Chapter 25 Solutions