Concept explainers
Interpretation:
A mechanism is to be proposed for the given reaction under conditions that favor an
Concept introduction:
An
In the second step, the nucleophile uses a lone pair on an atom like O to form a bond with the carbocation. If the incoming nucleophile is an uncharged specie like water or alcohol, a final deprotonation step involving any base present in the reaction mixture is necessary for the formation of the final product.
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Organic Chemistry: Principles and Mechanisms (Second Edition)
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- Draw a detailed, step-wise mechanism for the reaction shown below. SHOW ALL BOND-FORMING AND BOND-BREAKING STEPS. SHOW ALL INTERMEDIATES. 1) NaOH 2) H3O* H3C H3C HOarrow_forward2) Draw a plausible mechanism for the following reaction by using the guidelines, the template, and the instructions below. N H H3O+ H H₂N H 0: H • 14 H H + H H Harrow_forwardAnswer the question below the reaction. ta The reaction above proceeds through which type of mechanism? SN2 SN1 E1 E2 OH + Excess NH4C1 H₂SO4 + H₂Oarrow_forward
- OH Propose a mechanism for the reaction shown here. Note that the reaction does not take place without the presence of AICI3. 8, AICI3 2. H2Oarrow_forwardGive one example of elimination reaction (E2) type. Show the reactants materials and the product. Draw the reaction mechanism?arrow_forwardg) h) i) j) Br Br OCH₂ DMSO HOCH, H₂O NaOCH DMSOarrow_forward
- The nucleophile approaches from the opposite side of the carbon with the leaving group in which reaction mechanism? O E2 O SN1 O SN2 O SN1 and SN2arrow_forward11. Determine whether each reaction occurs by an SN2, SN1, E1, and/or E2 reaction. Provide a detailed mechanism with curved arrows and the major product(s). OMs Br Br OH мон OH NaSH DMF NaOH H₂O, heat LDA DMF NaOH H₂O, heat HBr H, H₂O heatarrow_forwardWhen acetone is dissolved in either a slightly basic or a slightly acidic solution of oxygen-18 labeled water, H2180, oxygen-18 labeled acetone, (CH3)2C=180, is produced. This is a form of an isotopic exchange reaction between acetone and water. Provide a mechanism to account for this reaction in (a) basic solution and (b) acidic solution. Hint: Is the addition of the nucleophile reversible or irreversible? 180 + H,180 CH3 + Hо `CH3 Acid or base H3C H3Carrow_forward
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