Interpretation: The synthesis of given
Concept introduction: The replacement or substitution of one
Grignard reagent is prepared by the reaction of alkyl or aryl bromide with magnesium metal in the presence of ether. The reaction of Grignard reagent with an
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- 18.2 Which of the following nitrile groups is activated toward nucleophilic attack? N. NH 18.1 Draw the mechanism for the reaction below under (a) neutral conditions and (b) basic conditions. Under which conditions do you think the hydration reaction will proceed faster? Why? HO OH + H20 Cyclohexanone Cyclohexanone hydratearrow_forwardHO 17.8 Give the product. LOH Na₂Cr₂O7 ОНarrow_forward18.65 Propose a plausible synthesis for the following trans- formation. CH3 CH3 CH3arrow_forward
- Devise a synthesis of anastrozole, a drug used to reduce the recurrence of breast cancer (Section 22.18), from the given compounds. You may use any other needed organic compounds or inorganic reagents. CN Br Br HN- NC. anastrozolearrow_forwardEto 22.4 Propose a synthesis of the compound shown below using the malonic ester synthesis. OEt CO₂H am first find the a-carbon, then figure out the alkyl halidesarrow_forwardMeO 22.55 One potential synthesis of the anti-inflammatory and analgesic drug nabumetone is chloromethylation (Problem 22.48) of 2-methoxynaphthalene followed by an acetoacetic ester synthesis (Section 19.6). 5 3 6 CH₂O CI acetoacetic ester synthesis HC 7 MeO MeO 1 8 2-Methoxynaphthalene Nabumetone (a) Account for the regioselectivity of chloromethylation at carbon 6 rather than at carbon 5 or 7. (b) Show steps in the acetoacetic ester synthesis by which the synthesis of nabum- etone is completed.arrow_forward
- 18.20 Write a stepwise mechanism for each of the following reactions. (a) O CH OR DI O HOS OHIS NaOH, H₂O -NaOH, H₂O ARTH ans posms mus O Plz solve all parts within 30-40 I 11 upvote your answer D CH3 (b) H NaOD D₂O H CH3 ben a marrow_forwardMethylparaben is a common preservative used in cosmetics. What carboxylic acid and alcohol are needed to synthesize methylparaben by Fischer esterifi cation?arrow_forward19.4 Draw a mechanism for the reaction shown below. H-CI НО. CI hint-the first step is protonation of the carbonyl oxygenarrow_forward
- Problem 23 of 44 Submit Draw the major product of this reaction. Ignore inorganic byproducts. Assume that the water side product is continuously removed to drive the reaction toward products. NH2OH, TSOHarrow_forward16.4 Predict the major product(s) of the reactions. of Br₂ FeBr 3arrow_forwardWhat Grignard reagent and carbonyl compound can be used to prepare theantidepressant venlafaxine (trade name Effexor)?arrow_forward
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