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- The plasma of half-life of aspirin is t1/2 = 20 minutes; ibuprofen t1/2 = 2 hours. Both agents are dosed q 4 to 6 hours. Compared to ibuprofen, APAP's dosing can be much longer than it's plasma half-life because it is: 1. more toxic, so cannot be taken as often 2. more selective for COX1 than is ibuprofen 3. an irreversible inhibitorAnalyze the list of combinations per item and identify the type of therapeutic incompatibility. In answering the item, write/input the letter that corresponds to the best answer. Use capital letters only. A. Antagonism or reduction of beneficial effects B. Potentiation / Synergistic ADRs C. Changes in rate of biotransformation / excretion D. Causes formation of toxic metabolite E. Results to a false laboratory result F. Exacerbation of symptoms G. Not a therapeutic incompatibility H.Intentional combination 1.biotin + thyroxine = 2.atropine + phenobarbital = 3.aspirin + serum bilirubin = 4.lovastatin + grapefruit = 5.streptomycin + serum creatinine = 6.captopril + naproxen = 7.verapamil + orange juice = 8.paracetamol + serum glucose = 9.broccoli + warfarin = 10.indomethacin + quinapril =Naloxone is sometimes added to PO phenanthrene formulations to reduce injection abuse while retaining pain relief when used properly. Naltrexone is not used in this way because naltrexone: 1. is orally bioavailable 2. will reduce conversion of the opioid pro-drug 3. will cross the blood brain barrier. 4. has a longer half-life 5. should only be used for opioid maintenance therapy
- A patient has a prolonged PT and normal aPTT, he is most likely has: O a. Deficiency of factor VII. O b. Any of the answers is a possibility. O c. Liver disease. O d. Vitamin K deficiency. O e. Warfarin therapy.If the patient is given amlodipine, which of the following would be a possibility at therapeutic doses? [Select all that apply] Decreased HR due to L-type calcium channel inhibition Increased HR due to L-type calcium channel inhibition Decreased blood pressure due to L-type calcium inhibition Decreased HR due to Beta 1 adrenergic receptor inhibitionAll of the following are indications for acarbose use, except:A. Monotherapy for type II diabetesB. Monotherapy for type I diabetesC. Combination therapy with insulin for type I diabetesD. Combination therapy with glimepiride for type II diabetesE. Combination therapy with insulin for type II diabetes
- Side effects of fluoroquinolones includes all of the followings except: Teeth growth abnormalities a. O b. QT interval prolongation O C. Tendinitis O d. Diarrhea.dosage cal 1. A provider prescribes dopamine 400 mg in 250 mL D5W to start at 20 mcg/kg/min for a client weighing 148 lb. What is the mL per hour? 2. A provider prescribes dopamine 400 mg in 250 mL D5W to start at 15 mcg/kg/min for a client weighing 64 kg. What is the mL per hour? 8. A client weighs 120 lb. Heparin IV infusion: Heparin sodium 20,000 units in 1,000 mL of D5W. The protocol is to give a bolus to the client with 50 units/kg and start the drip at 14 units/kg/hour Calculate the following: How many units should be administered with the Heparin bolus? 9. A client weighs 130 lb. Heparin IV infusion: Heparin sodium 20,000 units in 1,000 mL of D5W. The protocol is to give a bolus to the client with 25 units/kg and start the drip at 14 units/kg/hour Calculate the following: How many units should be administered with the Heparin bolus? 10. A provider orders 100 mL of albumin to be infused over 30 minutes. The drop factor is 15 drops per mL. How many drops per minute should…a) Define EDso and TDso. Calculate the therapeutic index (TI) for each of the following drugs based on the dose-response curves provided. Comment on the safety of these two treatments. 100 80- 60- 40- 20- Drug 1 Therapeutic effect Toxic effect 100 200 300 400 500 600 700 Drug dose (mg) 100- Therapeutic effect 80- 60- 17 40- 20- 0- 10 20 Drug 2 40 Toxic effect 60 80 100 120 Drug dose (mg) 140
- Do not include zeros at the end of decimal numbers. The problems and drug orders are presented for practice only, and actual prescribed factors. ler 1 mL to two decimal places. Order: Vantin 200 mg p.o., q.12h Supply: Vantin 100 mg/5 mL After reconstitution, the vial contains 50 mL. Give: Moving to another question will save this response. Type here to search mAntidiabetic therapeutic alternatives' costs and outcomes are shown in the table below. Treatment Outcome (reduction in A1C mg/dL) Cost 3 JD 1 Y 1.5 JD 1 6 JD 1.3 W 6 JD 1.5 Which of the treatment alternatives can be evaluated using CMA? Select one: O a. X and Y O b. X, Y and Z O c. All O d. Z and WIn a placebo-controlled study, 10 healthy subjects were given oral triazolam 0.5 mg before and after rifampicin 600 mg daily for 5 days. Rifampicin reduced the triazolam AUC by 95% and decreased its maximum plasma levels by 88%, when compared with placebo. The elimination half-life was reduced from 2.8 hours to 1.3 hours. Pharmacodynamic tests (drowsiness, sway, Maddox wing, etc.) showed that rifampicin abolished the effects of triazolam.a) Why is the AUC of triazolam reduced in the presence of rifampicin? b) Given the above scenario, if you were to accommodate this situation by dosage adjustment strategies, in the presence rifampicin what dose of triazolam would you have recommended, keeping dosage interval the same as when there was no rifampicin? answer part b