Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Question
Chapter 27, Problem 18P
Interpretation Introduction
(a)
Interpretation:
About Leptin’s mechanism of action.
Concept Introduction:
Mechanisms of Leptin action and Leptin resistance. The fatty tissue-derived secretion Leptin acts via its receptor (LRb) within the brain to manage energy balance and system perform. LRb signal via STAT3 and variety of different pathways is needed for the totality of Leptin action.
Interpretation Introduction
(b)
Interpretation:
About loss of function in a protein.
Concept Introduction:
Leptin binds to its receptors (Leptin receptors) having a specific membrane-spanning protein expressed within the central nervous system. Once Leptin binds to its receptors, it starts a complex and tough signal transduction pathway linking to the hormone transduction pathway.
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Q1. Explain why GDP cannot dissociate from the alpha subunit of the Trimeric G-protein even though
the receptor is activated by ligand binding and there is enough GTP for the exchange process.
MULTIPLE CHOICE
In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not
A. decrease de novo pyrimidine synthesis
B. decrease de novo purine synthesis
C. decrease urate synthesis
D. increase PRPP levels (Phosphoribosyl pyrophosphate)
In expressing therapeutic proteins (check all that apply):
O Bacteria could be used if you want the protein's disulfide bonds formed before secretion from the bacterial cell.
The N-terminal signal sequence and the C chain of insulin must be cleaved off in the rough ER before it's active.
O Proteolytic protein maturation can be performed by mammalian cells.
□ One of the required modifications to preproinsulin, before it's mature, is glycosylation.
Both preproinsulin and proinsulin are inactive proteins.
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