Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Question
Chapter 27, Problem 3P
Interpretation Introduction
Interpretation:
The time required to last 8 mM of ATP when ATP consumed by muscle is
Concept introduction:
The relation between
Here, R is Universal gas constant, T is temperature,
The reaction is spontaneous if the value of change in Gibbs free energy is negative.
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Intracellular concentrations in resting muscle are as follows: fructose6-phosphate, 1.0 mM; fructose-1,6-bisphosphate, 10 mM; AMP, 0.1 mM;ADP, 0.5 mM; ATP, 5 mM; and Pi, 10 mM. Is the phosphofructokinasereaction in muscle more or less exergonic than under standard conditions?By how much?
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The sarcoplasmic reticulum Ca2+-ATPase, pumps 2 mol Ca2+ out of sarcomeres per mol ATP hydrolyzed.(a) Given the following steady-state concentrations and a membrane potential of 65 mV (inside negative), calculate ΔG for the following activetransport process at 37 °C and pH = 7.4:2Ca2+(in) + ATP + H2O → 2Ca2+(out) + ADP + Pi + H+ATP = 2.6 mM, ADP = 210 μM, Pi = 5.1 mM, Ca2+(in) = 32 mM,Ca2+(out) = 2.2 mM(b) In active muscle the pH can drop below 7.4. Is the reaction above moreor less favorable under these conditions?(c) The activity of the Ca2+-ATPase is regulated reversibly under normalconditions to maintain homeostatic concentrations of Ca2+ inside thesarcomere. However, in a rare genetic disorder, irreversible activation ofthe Ca2+ -ATPase can occur. Assuming 37 °C, pH = 7.4, and the steadystate concentrations for ATP, ADP Pi, and Ca2 +(out) given in part (a),calculate the minimum [Ca2 +] inside a sarcomere that has irreversibly activated Ca2 +-ATPase (i.e., the Ca2 +-ATPase…
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