Biochemistry
Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
Question
Book Icon
Chapter 27, Problem 3P
Interpretation Introduction

Interpretation:

The time required to last 8 mM of ATP when ATP consumed by muscle is 300 μmol/min .The decrease in the concentration of the ATP before its complete consumption in the reaction needs to be determined.

Concept introduction:

The relation between ΔG and ΔG°' of the reaction is as follows:

  ΔG=ΔG°'+RT ln[product][reactant]

Here, R is Universal gas constant, T is temperature, [product] is concentration of product and [reactant] is concentration of reactant.

The reaction is spontaneous if the value of change in Gibbs free energy is negative.

Blurred answer
Students have asked these similar questions
Intracellular concentrations in resting muscle are as follows: fructose6-phosphate, 1.0 mM; fructose-1,6-bisphosphate, 10 mM; AMP, 0.1 mM;ADP, 0.5 mM; ATP, 5 mM; and Pi, 10 mM. Is the phosphofructokinasereaction in muscle more or less exergonic than under standard conditions?By how much?
Intracellular concentrations in resting muscle are as follows: fructose- 6-phosphate, 1.0 mM; fructose-1,6-bisphosphate, 10 mM; AMP, 0.1 mM; ADP, 0.5 mM; ATP, 5 mM; and P, 10 mM. Is the phosphofructokinase reac- tion in muscle more or less exergonic than under standard conditions? By how much?
The sarcoplasmic reticulum Ca2+-ATPase, pumps 2 mol Ca2+ out of sarcomeres per mol ATP hydrolyzed.(a) Given the following steady-state concentrations and a membrane potential of 65 mV (inside negative), calculate ΔG for the following activetransport process at 37 °C and pH = 7.4:2Ca2+(in) + ATP + H2O → 2Ca2+(out) + ADP + Pi + H+ATP = 2.6 mM, ADP = 210 μM, Pi = 5.1 mM, Ca2+(in) = 32 mM,Ca2+(out) = 2.2 mM(b) In active muscle the pH can drop below 7.4. Is the reaction above moreor less favorable under these conditions?(c) The activity of the Ca2+-ATPase is regulated reversibly under normalconditions to maintain homeostatic concentrations of Ca2+ inside thesarcomere. However, in a rare genetic disorder, irreversible activation ofthe Ca2+  -ATPase can occur. Assuming 37 °C, pH = 7.4, and the steadystate concentrations for ATP, ADP Pi, and Ca2 +(out) given in part (a),calculate the minimum [Ca2 +] inside a sarcomere that has irreversibly activated Ca2 +-ATPase (i.e., the Ca2 +-ATPase…
Knowledge Booster
Background pattern image
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
  • Text book image
    Biochemistry
    Biochemistry
    ISBN:9781305577206
    Author:Reginald H. Garrett, Charles M. Grisham
    Publisher:Cengage Learning
    Text book image
    Biology 2e
    Biology
    ISBN:9781947172517
    Author:Matthew Douglas, Jung Choi, Mary Ann Clark
    Publisher:OpenStax
Text book image
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Text book image
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax