Principles of Biology
2nd Edition
ISBN: 9781259875120
Author: Robert Brooker, Eric P. Widmaier Dr., Linda Graham Dr. Ph.D., Peter Stiling Dr. Ph.D.
Publisher: McGraw-Hill Education
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Chapter 6.7, Problem 3CC
Summary Introduction
To determine:
The conformation of β subunits on the left and the back right if the β subunit in the front center is in conformation 2.
Introduction:
The adenosine triphosphate (ATP) synthase is known to be a rotary machine with moving parts that are powered by a source of energy. It is involved in the process of synthesizing ATP.
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Students have asked these similar questions
The amino acid shown below has an ionizable side chain with a pka of 4.
When this amino acid is in a more basic solution (i.e., pH 11), it would resemble ionization
state C
and have a charge of -1
HO
OH
NH₂
lonization state A
NH3
lonization state C
HO
OH
NH3+
Ionization state B
dyb
NH₂
lonization state D
Help me
Small molecules are used as inhibitors of protein action - as drugs. They most often do this
by blocking the active site within the protein. Potential drugs can be screened
computationally to determine if they are strongly bound to the protein.
Figure 1 shows a possible conformation of a candidate drug molecule, 4-bromo-2-
carboxymethylamide-pyrrole (abbreviation: BCMAP) at the active site of a protein
(abbreviation: PR). Figure 2 shows the full protein structure whilst figure 3 shows a known
inhibitor of the protein at the site, overlayed with another calculated conformer of BCMAP.
(c) Outline how you would investigate whether BCMAP would be an effective inhibitor
for the protein in competition with the molecules that the protein normally targets,
and any solvent.
Figure 1. 4-bromo-2-carboxymethylamide-pyrrole (BCMAP) (C, N, O, and Br atoms in yellow, blue,
red, and brown, respectively) in the active site of the protein structure.
Chapter 6 Solutions
Principles of Biology
Ch. 6.1 - Which do you think has more entropy, an NaCl...Ch. 6.1 - Prob. 1TYKCh. 6.1 - Prob. 2TYKCh. 6.2 - Prob. 1CCCh. 6.2 - Prob. 2CCCh. 6.2 - Prob. 3CCCh. 6.2 - Prob. 1TYKCh. 6.2 - An inhibitor raises the Km for an enzyme but has...Ch. 6.3 - Prob. 1CCCh. 6.3 - Prob. 1TYK
Ch. 6.3 - Prob. 2TYKCh. 6.3 - Prob. 3TYKCh. 6.4 - Prob. 1CCCh. 6.4 - Prob. 1BCCh. 6.4 - Prob. 1TYKCh. 6.4 - Prob. 2TYKCh. 6.4 - Prob. 2CCCh. 6.5 - Prob. 1TYKCh. 6.6 - During the citric acid cycle, what happens to...Ch. 6.7 - Prob. 1CCCh. 6.7 - Prob. 2CCCh. 6.7 - Prob. 3CCCh. 6.7 - Prob. 1TYKCh. 6.7 - Prob. 2TYKCh. 6.7 - Prob. 3TYKCh. 6.8 - Prob. 1CCCh. 6.8 - Prob. 1TYKCh. 6 - According to the second law of thermodynamics....Ch. 6 - Reactions that release free energy are exergonic....Ch. 6 - Prob. 3TYCh. 6 - Prob. 4TYCh. 6 - Prob. 5TYCh. 6 - Prob. 6TYCh. 6 - Prob. 7TYCh. 6 - Prob. 8TYCh. 6 - Prob. 9TYCh. 6 - Prob. 10TYCh. 6 - Describe the mechanism and purpose of feedback...Ch. 6 - What causes the rotation of the y subunit of ATP...Ch. 6 - PRINCIPLES A principle of biology is that living...Ch. 6 - Discuss how life can maintain its order in spite...Ch. 6 - Prob. 2CBQ
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