Principles of Biology
Principles of Biology
2nd Edition
ISBN: 9781259875120
Author: Robert Brooker, Eric P. Widmaier Dr., Linda Graham Dr. Ph.D., Peter Stiling Dr. Ph.D.
Publisher: McGraw-Hill Education
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Chapter 6, Problem 2CCQ

What causes the rotation of the y subunit of ATP synthase? How does this rotation promote ATP synthesis?

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What is the effect of the mutation on succinate-coupled ATP synthesis?
Discuss the composition of the transition state for the formation of ATP by ATP Synthase. a) Where is the active site for this enzyme located? b) How are the amino acid side chains from the α and β subunits of ATP Synthase involved? c) Discuss the importance of Mg+2 in the mechanism of this enzyme.
According to Paul Boyer, the mechanism of ATP synthesis involves the rotation of the y subunit which in turn causes sequential conformation changes in the aß assemblies. Explain the steps of ATP synthesis according to this mechanism.
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