Principles of Biology
2nd Edition
ISBN: 9781259875120
Author: Robert Brooker, Eric P. Widmaier Dr., Linda Graham Dr. Ph.D., Peter Stiling Dr. Ph.D.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 6, Problem 3CCQ
PRINCIPLES A principle of biology is that living organisms maintain homeostasis. How is glucose breakdown regulated to maintain homeostasis? What vould be some potentially harmful consequences if glucose
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The enzyme hexokinase binds to glucose at lower glucose concentrations than does the enzyme glucokinase, but glucokinase only binds to glucose (and not to other hexose sugars). This means that:
glucokinase has a stronger affinity but a lower specificity for glucose than does hexokinase
glucokinase has a stronger affinity and a higher specificity for glucose than does hexokinase
glucokinase has a lower affinity but a higher specificity for glucose than does hexokinase
glucokinase has a lower affinity and a lower specificity for glucose than does hexokinase
all of the above
Which statement about the control of metabolism is true?
In an amphibolic pathway, the regulated reaction can be reversible.
Each metabolic pathway has unique reactions through which the whole pathway is controlled.
Since metabolic pathways are interdependent, the regulated reactions can be identical between pathways.
Biosynthetic and degradative pathways have nothing in common.
O Only reversible reactions can be used to regulate the whole pathway.
Answer this Question
Would increasing the concentration of glucose be a physiologically reasonable way to increase the concentration of G6P?
Yes. [Glucose] is lower than [G6P], so adding glucose would shift the equilibrium to the right.
No. The glucose concentration would need to be higher than the maximum solubility of glucose.
No. Because the concentration of Pi is lower than the concentration of glucose, Pi is the limiting reactant.
Yes. The glucose concentration would be higher than the concentration of G6P, so the reaction would proceed.
Chapter 6 Solutions
Principles of Biology
Ch. 6.1 - Which do you think has more entropy, an NaCl...Ch. 6.1 - Prob. 1TYKCh. 6.1 - Prob. 2TYKCh. 6.2 - Prob. 1CCCh. 6.2 - Prob. 2CCCh. 6.2 - Prob. 3CCCh. 6.2 - Prob. 1TYKCh. 6.2 - An inhibitor raises the Km for an enzyme but has...Ch. 6.3 - Prob. 1CCCh. 6.3 - Prob. 1TYK
Ch. 6.3 - Prob. 2TYKCh. 6.3 - Prob. 3TYKCh. 6.4 - Prob. 1CCCh. 6.4 - Prob. 1BCCh. 6.4 - Prob. 1TYKCh. 6.4 - Prob. 2TYKCh. 6.4 - Prob. 2CCCh. 6.5 - Prob. 1TYKCh. 6.6 - During the citric acid cycle, what happens to...Ch. 6.7 - Prob. 1CCCh. 6.7 - Prob. 2CCCh. 6.7 - Prob. 3CCCh. 6.7 - Prob. 1TYKCh. 6.7 - Prob. 2TYKCh. 6.7 - Prob. 3TYKCh. 6.8 - Prob. 1CCCh. 6.8 - Prob. 1TYKCh. 6 - According to the second law of thermodynamics....Ch. 6 - Reactions that release free energy are exergonic....Ch. 6 - Prob. 3TYCh. 6 - Prob. 4TYCh. 6 - Prob. 5TYCh. 6 - Prob. 6TYCh. 6 - Prob. 7TYCh. 6 - Prob. 8TYCh. 6 - Prob. 9TYCh. 6 - Prob. 10TYCh. 6 - Describe the mechanism and purpose of feedback...Ch. 6 - What causes the rotation of the y subunit of ATP...Ch. 6 - PRINCIPLES A principle of biology is that living...Ch. 6 - Discuss how life can maintain its order in spite...Ch. 6 - Prob. 2CBQ
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- The human hormone insulin causes liver cells to increase the rate they convert glucose to glycogen for storage. Based on this information, which of the following might occur in a liver cell exposure to insulin? Choose only the best response based only information presented in this course. The amount of the enzyme converting glucose to glycogen might decrease. All of the other options could occur. The enzyme converting glucose to glycogen might be phosphorylated, thereby increasing its rate of activity. The amount of CAMP in the cell might decrease, activating protein kinase A.arrow_forwardThe enzyme glucokinase binds to glucose at higher glucose concentrations than does the enzyme hexokinase, but glucokinase only binds to glucose (and not to other hexose sugars). This means that: glucokinase has a higher affinity and a higher specificity for glucose than does hexokinase glucokinase has a higher affinity but a lower specificity for glucose than does hexokinase glucokinase has a lower affinity but a higher specificity for glucose than does hexokinase glucokinase has a lower affinity and a lower specificity for glucose than does hexokinase all of the abovearrow_forwardPhosphofructokinase (PFK) is and enzyme in Glycolysis, and an important control enzyme in the regulation of cellular respiration. Which of the following statements concerning phosphofructokinase is not true? O it is stimulated by citric acid OIt is an example of feedback inhibition o it is an allosteric enzyme O it is inhibited by citric acid O it is stimulated by AMP O it is inhibited by ATP • Previous Next 近arrow_forward
- Which of the following statements about glucose metabolism is correct? A. Glucagon increases the rate of glycolysis B. Glycolysis requires NADP+ C. In glycolysis, glucose is cleaved into two three-carbon product D. The end-product of glycolysis in red blood cells is pyruvate E. Glycogen is synthesized in the liver in response to insulin and exported to other tissues for use as a metabolic fuelarrow_forwardIn hepatocytes, the enzyme glucokinase catalyzes the ATP-coupled phosphorylation of glucose. Glucokinase binds both ATP and glucose, forming a glucose-ATP-enzyme complex. The enzyme then transfers the phosphoryl group directly from ATP to glucose. Select the advantages of phosphoryl group transfer compared to hydrolysis and subsequent phosphorylation? Glucokinase increases the transition state energy, favoring glucose phosphorylation. Reaction intermediates do not need to be present in excess. The process takes advantage of the high phosphoryl group transfer potential of ATP. ATP hydrolysis is thermodynamically unfavorable compared to group transfer.arrow_forwardIt makes sense that enzymes should be active when they are needed and inactive when they are not needed. Non-competitive (allosteric) regulation of enzymes is important in metabolism because it allows for the rapid adjustment of their activity. Recall hexokinase, a key enzyme of glycolysis. Which of the following molecules likely functions as an allosteric inhibitor of its activity? A. ADP B. Glucose C. NAD+ D. Pyruvatearrow_forward
- The enzyme aldolase catalyzes the fourth step of glycolysis. This enzyme has a zinc ion (Zn2+) bound in its active site. This ion likely binds which of the following amino acids? a.A b.K c.S d.G e.Darrow_forwardHomeostatic systems maintain a steady-state set point over time using negative feedback. Which one of the following statement is NOT TRUE for stability of metabolic system: Select one: a. Step changes in a controlled variable will return the system to its original state using negative feedback b. Metabolic systems that oscillate must have multiple control variables c.A positive feedback system is stable over time, maintaining a steady state d. Perturbations from steady state, either positive or negative, result in recovery reactions that returm the system to is original state.arrow_forwardQuite often, medications cannot be taken with grapefruit juice. This is becausegrapefruit juice blocks an enzyme responsible for metabolism of the drug. Chemicals ingrapefruit juice bind to the active site of the enzyme. What type of inhibition is this, andwhat would it do to the amount of medication in your blood? Why is this bad for you explain?arrow_forward
- Which of the following is a primary function of the active site of an enzyme? a. It binds allosteric regulators of the enzyme. b. It binds noncompetitive inhibitors of the enzyme. c. It catalyzes the reaction associated with the enzyme. d. It is activated by the presence of the end product of the metabolic pathway in which the enzyme is involved. Clear my choice Question 2 Not yet answered Points out of 2.00 Flag question Question text Which of the following statement about the mass spectrometry is true? a. Large amount of protein sample is needed for mass spectrum, and thus it is very expensive. b. It is a powerful method to determine the 3-dimensional structure of proteins. c. It can be sued for protein location in a living cell. d. It can be used to measure the molecular weight of proteins. e. It can be used to determine the stability of a protein structure in solution. Clear my choice…arrow_forwardAfter infection, some T cells (a particular type of immune cell) may persist as memory T cells (TMcells). When they re-encounter the same pathogen, TM cells rapidly divide to produce more T cells to help fight off the infection. This rapid cell division requires substantial energy. One way that this energy is provided to TMcells is via increased activity of the ETC. One standard type of experiment for analyzing oxidative metabolism is measuring the oxygen consumption rate OCR in the presence of different compounds. The lines indicate the time at which the different ETC/OxPhos inhibitors were added. Note that the inhibitors are never removed. Complete the table below. Time Period 1 2 3 4 Inhibitor added None Oligomycin (inhibits ATP Synthase) FCCP (Uncoupler) Rotenone + Antimycin (Complexes I and III) Can electrons flow? If so, from which compound to which compound? If not, what is preventing it? Can H+move through the membrane? If so,…arrow_forwardFructose and glucose are both monosaccharides, but the body metabolizesthese sugars differently. For example, glucose stimulates insulin releasefrom the pancreas (see section 28.4); fructose does not. Moreover, insulinstimulates leptin release. Finally, fructose is more likely than glucose tobe converted to fat. Use this information to propose an explanation for thecorrelation between the skyrocketing consumption of high fructose cornsyrup since 1970 and the rise in obesity during the same period.arrow_forward
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