Chapter 10, Problem 10.55SP

(a)

Interpretation Introduction

To determine: The synthesis of the given deuterium-labelled compound ${\text{CH}}_{\text{3}}\text{CH}\left(\text{OD}\right){\text{CD}}_3$ using ${\text{LiAlD}}_{\text{4}}$ and ${\text{D}}_{\text{2}}\text{O}$, and any non-deuterated compound as starting material.

Interpretation: The synthesis of the given deuterium-labelled compound ${\text{CH}}_{\text{3}}\text{CH}\left(\text{OD}\right){\text{CD}}_3$ using ${\text{CD}}_3\text{MgBr}$ and ${\text{D}}_{\text{2}}\text{O}$, and any non-deuterated compound as starting material is to be shown.

Concept introduction: Compounds that contains deuterium $\left(\text{D}=\text{H}\right)$ are very useful in kinetic studies and metabolic studies with new pharmaceuticals. Deuterium is also introduced by using reagent ${\text{CD}}_3\text{MgBr}$.

Deuterium is one of the isotopes of hydrogen atom that contains one neutron.

(b)

Interpretation Introduction

To determine: The synthesis of the given deuterium-labelled compound ${\text{CH}}_{\text{3}}\text{C}\left(\text{OH}\right){\left({\text{CD}}_3\right)}_2$ using ${\text{LiAlD}}_{\text{4}}$ and ${\text{D}}_{\text{2}}\text{O}$, and any non-deuterated compound as starting material.

Interpretation: The synthesis of the given deuterium-labelled compound ${\text{CH}}_{\text{3}}\text{C}\left(\text{OH}\right){\left({\text{CD}}_3\right)}_2$ using ${\text{CD}}_3\text{MgBr}$ and ${\text{D}}_{\text{2}}\text{O}$, and any non-deuterated compound as starting material is to be shown.

Concept introduction: Compounds that contains deuterium $\left(\text{D}=\text{H}\right)$ are very useful in kinetic studies and metabolic studies with new pharmaceuticals. The deuterium is also introduced by using reagent ${\text{CD}}_3\text{MgBr}$.

Deuterium is one of the isotopes of hydrogen atom that contains one neutron.

(c)

Interpretation Introduction

To determine: The synthesis of the given deuterium-labelled compound ${\text{CD}}_{\text{3}}{\text{CH}}_2{\text{CH}}_2\text{OH}$ using ${\text{LiAlD}}_{\text{4}}$ and ${\text{D}}_{\text{2}}\text{O}$, and any non-deuterated compound as starting material.

Interpretation: The synthesis of the given deuterium-labelled compound ${\text{CD}}_{\text{3}}{\text{CH}}_2{\text{CH}}_2\text{OH}$ using ${\text{CD}}_3\text{MgBr}$ and ${\text{D}}_{\text{2}}\text{O}$, and any non-deuterated compound as starting material is to be shown.

Concept introduction: Compounds that contains deuterium $\left(\text{D}=\text{H}\right)$ are very useful in kinetic studies and metabolic studies with new pharmaceuticals. The deuterium is also introduced by using reagent ${\text{CD}}_3\text{MgBr}$.

Deuterium is one of the isotopes of hydrogen atom that contains one neutron.

(d)

Interpretation Introduction

To determine: The synthesis of the given deuterium-labelled compound $\text{Ph}{\left({\text{CD}}_3\right)}_2\text{COD}$ using ${\text{LiAlD}}_{\text{4}}$ and ${\text{D}}_{\text{2}}\text{O}$, and any non-deuterated compound as starting material.

Interpretation: The synthesis of the given deuterium-labelled compound $\text{Ph}{\left({\text{CD}}_3\right)}_2\text{COD}$ using ${\text{CD}}_3\text{MgBr}$ and ${\text{D}}_{\text{2}}\text{O}$, and any non-deuterated compound as starting material is to be shown.

Concept introduction: Compounds that contains deuterium $\left(\text{D}=\text{H}\right)$ are very useful in kinetic studies and metabolic studies with new pharmaceuticals. The deuterium is also introduced by using reagent ${\text{CD}}_3\text{MgBr}$.

Deuterium is one of the isotopes of hydrogen atom that contains one neutron.