To assign E or Z configuration to the double bonds in Tamoxifen and Clomiphene. Concept introduction: The member that ranks higher can be determined by considering the atomic number of the first atom of the two substituents separately. The atom with highest atomic number gets a higher rank. If a decision cannot be made by considering the atomic number of the first atom in each substituent then the second, third, fourth atoms away from double bond are considered until the first difference is found. Multiple bonded atoms are considered as equivalent to the same number of single bonded atoms. The isomer that has the higher ranked groups on each carbon are on the same side of the double bond is said to have Z configuration. If the higher ranked groups are on opposite sides, the alkene is said to have E configuration. To assign: The configuration for the double bonds in Tamoxifen and Clomiphene as E or Z.

Question

Two useful organic compounds that contain Cl atoms are vinyl chloride (CH2 = CHCI) and chloroethane (CH;CH;CI). Vinyl chloride is the starting material used to prepare poly (vinyl chloride), a plastic used in insulation, pipes, and bottles. Chloroethane (ethyl chloride) is a local anesthetic. Why is the C- Cl bond of vinyl chloride stronger than the C– CIl bond in chloroethane.

Answer 1

Question

Chapter 7.SE, Problem 53AP

Interpretation Introduction

Interpretation:

To assign E or Z configuration to the double bonds in Tamoxifen and Clomiphene.

Concept introduction:

The member that ranks higher can be determined by considering the atomic number of the first atom of the two substituents separately. The atom with highest atomic number gets a higher rank. If a decision cannot be made by considering the atomic number of the first atom in each substituent then the second, third, fourth atoms away from double bond are considered until the first difference is found. Multiple bonded atoms are considered as equivalent to the same number of single bonded atoms. The isomer that has the higher ranked groups on each carbon are on the same side of the double bond is said to have Z configuration. If the higher ranked groups are on opposite sides, the alkene is said to have E configuration.

To assign:

The configuration for the double bonds in Tamoxifen and Clomiphene as E or Z.

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