Principles of Biology
Principles of Biology
2nd Edition
ISBN: 9781259875120
Author: Robert Brooker, Eric P. Widmaier Dr., Linda Graham Dr. Ph.D., Peter Stiling Dr. Ph.D.
Publisher: McGraw-Hill Education
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Chapter 19, Problem 2CCQ
Summary Introduction

To determine:

The percentage of individuals that would be expected to be heterozygous carriers, on the basis of Hardy- Weinberg equilibrium.

Introduction:

Hardy-Weinberg principle deals with gene frequency change in the random mating population. According to Hardy- Weinberg principle, the genotype frequencies remain in the proportion p2 (AA), 2pq (Aa), and q2 (aa). Hardy-Weinberg equation for allele frequency is p+q = 1 and for genotype frequency is p2+2pq+q2 = 1.

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In a population of 200 people, an allele F has a frequency of 84%. What is the frequency of allele f? Using the Hardy-Weinberg equation, estimate the numbers of homozygous dominant, heterozygous, and homozygous recessive genotypes. (Remember that the formula is: p2 + 2pq + q2 = 1, where p represents the dominant allele and q represents the recessive allele.) *Be sure to account for all 200 people in the population.
In a population at genetic equilibrium, the frequency of the dominant phenotype is 0.96. What are the frequencies of the dominant (A) and recessive (a) alleles, and what are the expected frequencies of the AA, Aa, and aa genotypes?
If a disease determined by autosomal recessive heredity occurs at a frequency of 0.04 in a population, what is the frequency of this disease allele in the population? Assume Hardy-Weinberg equilibrium and use Aand a to symbolize the dominant and recessive alleles, respectively. Show calculation.
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