Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 15, Problem 43RQ
Summary Introduction
To review:
The fact that the deficiency of tyrosinase causes albinism.
Introduction:
The genetic defect that involves the absence of any coloration in the person or animal is termed as albinism. Albinism can happen because of a mutation in the genome, diet, age, injury, or disease. It is a genetic defect that happens because of the deficiency of the enzyme that converts tyrosine in its
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QUESTION NO. 1 Cystic fibrosis is a frequent generic disease of Caucasians. The CF gene codes for a protein called the cystic fibrosis transmembrane conductance regulator (CFTR) which functions as a cAMP-regulated chloride channel. The protein has two membrane-spanning domains, two domains that interact with ATP, and one regulatory domain. The most common defect is in the gene for one of the ATP binding domains. The result is a protein that does not fold correctly in the endoplasmic reticulum, is not properly glycosylated, and is nor transported to the cell surface. Rather, it is degraded in the cytosol within proteasomes. Drugs that foster chaperone interaction with the mutant protein are a potential therapeutic approach. Chaperones
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Chapter 15 Solutions
Biochemistry: The Molecular Basis of Life
Ch. 15 - Prob. 1QCh. 15 - Prob. 2QCh. 15 - Prob. 5QCh. 15 - Prob. 6QCh. 15 - Prob. 7QCh. 15 - Prob. 1RQCh. 15 - Prob. 2RQCh. 15 - Prob. 3RQCh. 15 - Prob. 4RQCh. 15 - Prob. 5RQ
Ch. 15 - Prob. 6RQCh. 15 - Prob. 7RQCh. 15 - Prob. 8RQCh. 15 - Prob. 9RQCh. 15 - Prob. 10RQCh. 15 - Prob. 11RQCh. 15 - Prob. 12RQCh. 15 - Prob. 13RQCh. 15 - Prob. 14RQCh. 15 - Prob. 15RQCh. 15 - Prob. 16RQCh. 15 - Prob. 17RQCh. 15 - Prob. 18RQCh. 15 - Prob. 19RQCh. 15 - Prob. 20RQCh. 15 - Prob. 21RQCh. 15 - Prob. 22RQCh. 15 - Prob. 23RQCh. 15 - Prob. 24RQCh. 15 - Prob. 25RQCh. 15 - Prob. 26RQCh. 15 - Prob. 27RQCh. 15 - Prob. 28RQCh. 15 - Prob. 29RQCh. 15 - Prob. 30RQCh. 15 - Prob. 31RQCh. 15 - Prob. 32RQCh. 15 - Prob. 33RQCh. 15 - Prob. 34RQCh. 15 - Prob. 35RQCh. 15 - Prob. 36RQCh. 15 - Prob. 37RQCh. 15 - Prob. 38RQCh. 15 - Prob. 39RQCh. 15 - Prob. 40RQCh. 15 - Prob. 41RQCh. 15 - Prob. 42RQCh. 15 - Prob. 43RQCh. 15 - Prob. 44RQCh. 15 - Prob. 45FBCh. 15 - Prob. 46FBCh. 15 - Prob. 47FBCh. 15 - Prob. 48FBCh. 15 - Prob. 49FBCh. 15 - Prob. 50FBCh. 15 - Prob. 51FBCh. 15 - Prob. 52FBCh. 15 - Prob. 53FBCh. 15 - Prob. 54FBCh. 15 - Prob. 55SACh. 15 - Prob. 56SACh. 15 - Prob. 57SACh. 15 - Prob. 58SACh. 15 - Prob. 59SACh. 15 - Prob. 60TQCh. 15 - Prob. 61TQCh. 15 - Prob. 62TQCh. 15 - Prob. 63TQCh. 15 - Prob. 64TQCh. 15 - Prob. 65TQCh. 15 - Prob. 66TQCh. 15 - Prob. 67TQCh. 15 - Prob. 68TQCh. 15 - Prob. 69TQCh. 15 - Prob. 71TQCh. 15 - Prob. 72TQCh. 15 - Prob. 73TQCh. 15 - Prob. 74TQ
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